Molecular Mechanisms of Cancer Signal Transduction Program
Specific Research Projects
- Molecular characterization of the progranulin/EphA2 signaling axis in bladder cancer and mesothelioma.
- Mutagenic analysis of EphA2 to dissect the residues necessary for oncogenic signaling.
- Dissection of p107 mechanisms of action and regulation.
- Characterization of progranulin-evoked ubiquitination and trafficking of EphA2 and its relevance in modulating receptor oncogenic signals.
- Identification of novel p107-interacting proteins by proteomic approaches.
- IGF-IR and progranulin role in obesity.
After his graduate studies in Biochemistry at Universita’ degli Studi di Milano, Milan Italy, Dr. Morrione moved to USA in 1993 and he has been working in the field of cancer biology since his postdoctoral training at the Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA in the laboratory of Dr. Renato Baserga, one of the leading experts in IGF-IR oncogenic signaling. In 1997 Dr. Morrione joined the Faculty of Thomas Jefferson University in the Department of Microbiology. In 2002 after receiving an NIH/NIDDK Career Development Award Dr. Morrione joined the Department of Urology at Jefferson where from 2008 to 2018 serves as the Director for Urology Basic Science and Associate Professor. Dr. Morrione has now joined the Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, where he is currently Associate Professor (Research) and Director of the Molecular Mechanisms of Cancer Signal Transduction Program.